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Product Details
Glucosamine is required for the synthesis of proteoglycans, the molecules responsible for providing tendons, ligaments and cartilage their resiliency and strength. It also helps protect cartilage from the effects of mechanical stress. Sulfate, another component of proteoglycans, works synergistically with glucosamine to enhance cartilage repair and regeneration. Additionally, it provides a naturally occurring blend of hyaluronic acid (HA), chondroitin sulfate, glucosamine sulfate and amino acids to promote cartilage synthesis and joint integrity. To further encourage collagen formation, this formula is enhanced with l-lysine and l-proline. These amino acids are hydroxylated to form hydroxyproline and hydroxylysine, in a reaction involving vitamin C, forming the “glue” that holds collagen together. In the body, silica is found primarily in connective tissue and plays a role in collagen tissue formation. Devil’s claw and curcumin are included to support joint flexibility, function and comfort, in part by maintaining healthy eicosanoid metabolism.
Four vegetable capsules contain
- Glucosamine sulfate (crab, shrimp) (1,500 mg)
- Hydrolyzed type II collagen complex (chicken sternal cartilage) (400 mg)
- Providing (typical)
- Hydrolyzed type II collagen 60% (240 mg)
- Chondroitin sulfate 20% (80 mg)
- Hyaluronic acid 10 % (40 mg)
- L-proline (free-form) (500 mg)
- L-lysine HCl (500 mg)
- Ascorbic acid (200 mg)
- Silica (from Bambusa vulgaris (bamboo) extract (stem)) (15 mg)
- Devil’s claw (Harpagophytum procumbens) extract (root) (100 mg)
- (standardized to contain 5% harpagosides) (5 mg)
- Turmeric (Curcuma longa) extract (100 mg)
- (standardized to contain 95% curcuminoids) (95 mg)
- Ascorbyl palmitate (fat-soluble vitamin C) (40 mg)
Recommendations
Pure Encapsulations recommends 4 capsules per day, in divided doses, with 8–10 oz water, with meals. Refrigerate after opening.
Precautions
If pregnant or lactating, consult your physician before taking this product. Rare side effects of glucosamine and devil’s claw include nausea, heartburn, diarrhea and constipation, drowsiness, skin reactions, or headache. Curcumin (turmeric) is not recommended for individuals with bile duct obstruction. Glucosamine can interfere with certain blood thinning medications. Consult your physician for more information.
Cautions
Consult a health care practitioner prior to use if you have high blood pressure, glaucoma, and/or detrusor instability. For a dose above 3 capsules per day, consult a health care practitioner if you are of childbearing age, pregnant or breastfeeding. Consumption with natural health products (e.g. bitter orange extract, synephrine, octopamine), ephedra, or other drugs (e.g. ephedrine) which increase blood pressure is not recommended. Consult a health care practitioner prior to use if you are taking lithium. Consumption with other caffeine-containing products (e.g. medications, coffee, tea, colas, cocoa, guarana, mate) is not recommended. This product is not recommended as a substitute for sleep. At doses above 6 capsules per day, caffeine may cause anxiety, tachycardia (rapid heart rate), palpitations, insomnia, restlessness, nervousness, tremor and headache. Hypersensitivity is known to occur; in which case discontinue use.